RESICURE(TM) 46

RESICURE(TM) 46 - Names and Identifiers

Name	2-Methylimidazole
Synonyms	2MZ 2MI 2MZ-H 2MZ-PW NSC 21394 Curezol 2MZ Actiron 2MI Epicure MI 2 Epikure MI 2 Curezol 2MZ-P IMicure AMI 2 Denka CN 25 Glyoxalethyline RESICURE(TM) 46 p-Oxal-methyline 2-methyl-imidazol AKOS BBS-00004447 2-Methylimidazole 2-Methylglyoxaline 2-methyl-imidazole 2-Methyl imidazole 2-methyl-1h-imidazol Imidazole, 2-methyl- 1H-2-MethyliMidazole 2-methyl-1H-imidazole 1H-Imidazole,2-methyl- 1H-Imidazole, 2-methyl-
CAS	693-98-1
EINECS	211-765-7
InChI	InChI=1/C4H6N2/c1-4-5-2-3-6-4/h2-3H,1H3,(H,5,6)
InChIKey	LXBGSDVWAMZHDD-UHFFFAOYSA-N

RESICURE(TM) 46 - Physico-chemical Properties

Molecular Formula	C4H6N2
Molar Mass	82.1
Density	1.0500 (rough estimate)
Melting Point	142-143 °C (lit.)
Boling Point	267-268 °C (lit.)
Flash Point	155 °C
Water Solubility	Soluble in water and ethanol.
Solubility	780g/l
Vapor Presure	<1 mm Hg ( 0 °C)
Appearance	Solid
Color	White to light yellow
BRN	1368
pKa	14.44±0.10(Predicted)
PH	10.5-11.5 (100g/l, H2O, 20℃)
Storage Condition	2-8°C
Sensitive	Sensitive to air
Refractive Index	1.4970 (estimate)
MDL	MFCD00005190
Physical and Chemical Properties	Trait solid. melting point 142~143 ℃ boiling point 267~268 ℃ solubility: soluble in water, ethanol, slightly soluble in cold benzene.
Use	It is used as an intermediate of drug metronidazole, and is also a curing agent for epoxy resin and other resins.

RESICURE(TM) 46 - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	R22 - Harmful if swallowed R34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S25 - Avoid contact with eyes.
UN IDs	UN 3259 8/PG 2
WGK Germany	2
RTECS	NI7175000
TSCA	Yes
HS Code	29332990
Hazard Note	Harmful/Corrosive
Hazard Class	8
Packing Group	III
Toxicity	LD50 orally in Rabbit: 1500 mg/kg

RESICURE(TM) 46 - Upstream Downstream Industry

Raw Materials	Ammonia Ethylenediamine Acetonitrile Acetonitrile Acetaldehyde
Downstream Products	2-Methyl-5-nitroimidazole 2-Methyl-5-nitroimidazole-1-ethanol

RESICURE(TM) 46 - Reference

Reference

1. [IF=7.46] Yang Hu et al."Ultrasensitive luteolin electrochemical sensor based on zeolitic imidazolate frameworks-derived cobalt trioxide @ nitrogen doped carbon nanotube/amino-functionalized graphene quantum dots composites modified glass carbon electrode."Sensor A
2. [IF=4.155] Siqi Zhang et al."Step-wise immobilization of multi-enzymes by zirconium-based coordination polymer in situ self-assembly and specific absorption."J Inorg Biochem. 2020 Jul;208:111093
3. [IF=3.361] Fahim A. Qaraah et al."Facile route for C–N/Nb2O5 nanonet synthesis based on 2-methylimidazole for visible-light driven photocatalytic degradation of Rhodamine B."Rsc Adv. 2019 Dec;9(68):39561-39571

RESICURE(TM) 46 - Nature

Open Data Verified Data

needle-like crystals (benzene). Melting point 143-144 °c (136 °c). Boiling point 267 °c. Soluble in water, ethanol, slightly soluble in cold benzene.

Last Update：2024-01-02 23:10:35

RESICURE(TM) 46 - Preparation Method

Open Data Verified Data

there are ethylenediamine method and glyoxal method.

The ethylenediamine method is obtained by cyclization of ethylenediamine and acetonitrile in the presence of sulfur and then dehydrogenation under the catalysis of active nickel.
glyoxal method

Last Update：2022-01-01 10:57:13

RESICURE(TM) 46 - Introduction

It's hygroscopic. Easily soluble in water, pyridine and ethanol, slightly soluble in benzene, toxic to the skin, mucous membrane irritating and corrosive.

Last Update：2022-10-16 17:27:59

RESICURE(TM) 46 - Application

Open Data Verified Data

The intermediate of metronidazole in the manufacture of drugs is also the curing agent of epoxy resin and other resins.

Last Update：2025-08-19 16:24:40

RESICURE(TM) 46 - Safety

Open Data Verified Data

It is packed in iron or wooden barrels, lined with plastic bags, 30kg or 50kg per barrel. Store in a cool and ventilated place. Protection against heat, sun and moisture. According to the provisions of the storage and transportation of toxic chemicals.

Last Update：2022-01-01 10:57:13

RESICURE(TM) 46 - Reference Information

pH range of acid-base indicator discoloration	10.5
LogP	0.22 at 25℃
(IARC) carcinogen classification	2B (Vol. 101) 2013
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
trait	2-methylimidazole is white or pale yellow granular or columnar.
Use	2-methylimidazole is an intermediate of the drug metronidazole and the feed growth promoter dimethazole, it is also the curing agent of epoxy resin and other resins. As the medium-temperature curing agent for an epoxy resin, it can be used alone, but is mainly used as a curing accelerator for powder molding and powder coating. Hygroscopic, soluble in water, alcohol, difficult to dissolve in benzene. Irritant and corrosive to skin and mucous membranes. This product is used for the synthesis of metronidazole and diazole, and is also a curing agent for bad oxygen resin. It is used as the intermediate of drug metronidazole, and also the curing agent of epoxy resin and other resins. This product is the intermediate of drug metronidazole and feed growth promoter dimethazole, it is also the curing agent of epoxy resin and other resins. As the medium-temperature curing agent for an epoxy resin, it can be used alone, but is mainly used as a curing accelerator for powder molding and powder coating. It is an intermediate for the manufacture of drug metronidazole, and is also a curing agent for epoxy resins and other resins. Fiber fabric dye adjuvant. Organic Synthesis. used in the production of metronidazole, dinitroimidazole and other pharmaceutical intermediates; Can be used as curing agents such as epoxy resin, textile fiber dye adjuvant; additives used in the preparation of foam
Overview	2-methylimidazole, also known as dimethylimidazole, is a white needle-like crystal or crystalline powder at room temperature. Relative molecular mass 82.11. The melting point was 145-146 °c. Boiling point 267 °c. Can sublimate. Flash point 160 °c. Insoluble in ether, cold benzene, soluble in water, Alcohols, Ketones. Irritation of the skin and mucous membranes. Mouse oral ld501400 mg/kg. 2-methylimidazole is an intermediate for the production of Trichomonas pesticide metronidazole. It is also the curing agent and curing accelerator of epoxy resin and other resins, which occupies a special position in the amine curing agent. As the intermediate temperature curing agent of epoxy resin, it can be used alone, after heat treatment in a short time, A cured product having a high heat distortion temperature can be obtained. However, it is mainly used as a curing accelerator for powder molding and powder coating. It can be obtained by dehydrogenation of 2-methylimidazoline.
preparation method	1, using glyoxal, acetaldehyde and ammonia as raw materials, the crude 2-methylimidazole is formed after reaction, after sublimation and refining, the finished product can be obtained. 2, using ethylenediamine and acetonitrile as raw materials, the reaction was carried out in the presence of sulfur to form imidazoline, and then dehydrogenation was carried out at 200 ℃ in the presence of nickel catalyst, 2-methylimidazole can be prepared as a finished product. 3, with glyoxal and methylamine in the presence of formaldehyde reaction, can be obtained.
Process	is derived from the elimination and dehydrogenation of 2-methylimidazolines. The 2-methylimidazoline was heated to melt (m. P. 107 °c) and the active nickel was carefully added and the temperature was raised to 200-210 °c for 2H. The temperature is lowered to below 150 ° C., water is added to dissolve, hot pressure filtration is carried out to separate active nickel, the filtrate is concentrated to a temperature above 140 ° C., and discharge is cooled to obtain 2-methylimidazole. The product with purity more than 98% was produced by this method. The 1t product consumed 1095kg of ethylenediamine (95%) and 975kg of acetonitrile. A preferred method is to use glyoxal and aldehyde as starting materials.
production method	results from the elimination and dehydrogenation of 2-methylimidazolines. The 2-methylimidazoline was heated to melt (m. P. 107 °c) and the active nickel was carefully added and the temperature was raised to 200-210 °c for 2H. The temperature is lowered to below 150 ° C., water is added to dissolve, hot pressure filtration is carried out to separate active nickel, the filtrate is concentrated to a temperature above 140 ° C., and discharge is cooled to obtain 2-methylimidazole. The product with purity more than 98% was produced by this method. The 1t product consumed 1095kg of ethylenediamine (95%) and 975kg of acetonitrile. A preferred method is to use glyoxal and aldehyde as starting materials.
autoignition temperature	>600°C DIN 51794
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)